AEGIS: Assay-Aware Protocol Validation and Runtime Monitoring for Open-Source Liquid Handling Robots
AEGIS is a two-layer system for open-source liquid handlers such as the Opentrons OT-2. The first layer uses a large language model (LLM) combined with an assay rule database to detect protocol violations, achieving an F1 score of 0.97 on a multi-assay benchmark. The second layer applies PCA to pipette trajectories for runtime failure detection, reaching an average precision of 0.89. The system is open-source and demonstrates low-cost monitoring through cascade triage.
Why it matters: AEGIS enables reliable, low-cost detection of both protocol and runtime failures in open-source liquid handling robots, addressing a key gap in self-driving laboratory automation.
Full story at: arXiv Robotics ↗